Roses have a special pigment molecule, a particular form of anthocyanin, responsible for all the rich red-to-blue shades in the petals that delight gardeners and attract pollinating insects. This molecule is different from the pigments in every other flowering plant; it is glycosylated at two positions instead of one.2 A single enzyme does the job at both points. Without the glycosylation reaction at both ends, the molecule is unstable and cannot be soluble in water in the vacuoles of the cells in which it operates. A team of Japanese scientists investigated how this double-glycosylation reaction system might have evolved. They could find no intermediate. Reporting in Nature,1 they said that while other flowers use derivatives from a singly-glycosylated form, “this is evolutionarily precluded in roses by their different glycosylation pattern, which may be unique to members of the Rosaceae” (emphasis added in all quotes). They also stated with puzzlement,It is a mystery why this particular glycosyltransferase evolved independently in roses. The novelty of the RhGT1 enzyme therefore lies not only in its ability to catalyse glycosylation at two different sites on the anthocyanidin molecule but also in its apparent absence from other species.They prepared a phylogenetic tree based on this type of pigment-preparing enzyme family, but it ended up with the rose family on a branch all by itself.1Ogata et al., “Plant biochemistry: Anthocyanin biosynthesis in roses,” Nature, 435, 757-758 (9 June 2005) | doi: 10.1038/nature435757a.2Glycosylation replaces an OH (hydroxyl) group with a glucoside. This is performed by an enzyme called a glycosyltransferase, in the case of roses, RhGT1.Here is a small gap, but a gap nonetheless; no evidence for the evolution of this complex molecule and the enzyme that knows how to operate it – just an unconfirmed prediction from evolutionary theory. Surprised? Question: was evolutionary theory of any value in this investigation?(Visited 6 times, 1 visits today)FacebookTwitterPinterestSave分享0
The title of the post was inspired by David Allen, founder of GTD (Get Things Done); if you listen to him enough you’ll hear him say it.If you want better results than you are generating now, you have to become better than you are now.Putting Things in the Right OrderThere are a lot of areas you might improve upon, and in Sales business acumen is right at the top of that list. But not the very, very top.Your physical health is the most important factor when it comes to generating greater success. Without your physical health, you will lack the stamina and energy to perform at peak levels. You are going to generate your very best performance when you are in your best physical health.The answer to optimal health is simple, but it isn’t easy. It requires that you sleep more than you believe necessary. It also means you need to eat with health as the intention instead of pleasure (even though there are ways to accomplish both). You also have to maintain your hydration.This is all common sense, but too few practice it, especially people who are running and gunning, hustling and achieving.Mental ToughnessThe second most important factor in your success depends a great deal on the first factor, and that is your psychological health. Your mental stamina and mental toughness depend a great deal upon your physical health. But they also depend upon your underlying belief systems and your attitude.You may not believe that you have a philosophy of your own, but you do, and it is found in your belief structures. The question is whether it is serving you.Your personal philosophy, your mind’s operating system, is worth exploring, and it’s worth working on. For an immediate improvement, look at the new mindfulness work and the stoic philosophies (Of which Tim Ferris and Ryan Holliday are huge proponents, both who make that work easily accessible).If you really want to be a hustler, and by that I mean a truly successful salesperson, you need to be committed to yourself first and foremost. Before you dive into a new health regimen it’s important that you’re mindful as to why you are doing it. Your physical health is the foundation upon which your sales success is built.