a month agoJagielka explains leaving Everton for Sheffield United

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Jagielka explains leaving Everton for Sheffield Unitedby Paul Vegasa month agoSend to a friendShare the lovePhil Jagielka has explained his decision to leave Everton for Sheffield United.He made 385 appearances over the course of 12 years at Goodison Park and won 40 England caps.”I was at home when I got the phone call from Marcel (Brands, Everton’s director of football),” he told the Daily Mail.”So I just texted Tony Sage, the kitman, to chuck all my stuff in a bin bag and I went to meet him at the front of the entrance at Finch Farm. I didn’t want to go in. It just didn’t feel right to go in.”What do you expect me to get? A Louis Vuitton bag? It was fine. I just had a few pairs of boots, some socks and stuff. I knew I may never go back there. It was all ready to go from A to B.”I was just happy there was no abuse from (veteran kitman) Jimmy Martin – though I’ll probably get that on Saturday!” last_img read more

9 days ago​Gilmour reveals Lampard advice before Chelsea debut

first_imgAbout the authorAnsser SadiqShare the loveHave your say ​Gilmour reveals Lampard advice before Chelsea debutby Ansser Sadiq9 days agoSend to a friendShare the loveBilly Gilmour has spoken about the advice that he received from Frank Lampard before making his Chelsea debut.The 18-year-old got his chance to shine with the senior side against Sheffield United in August. He came off the bench in the 2-2 draw.Gilmour has now revealed the words he exchanged with boss Lampard before the match.”The night before, the gaffer kept asking if my family were coming down and saying make sure they come,” the Scotland U21 international told reporters.”We were 2-0 up and I’m thinking ‘this could be good’, but it was 2-1 when I came on. “That shows you how much trust he has in the younger players to put you on in such a tight game.”It finished 2-2, which wasn’t the result I hoped for, but it made my dream come true of playing in the Premier League.” last_img read more

BENS BLOG A HUGE THANK YOU to Kevan Morretti

first_imgBlog, the fantastic news has come through, that Greyhound Racing will be remaining on Sky Sports.Some time ago, Star Sports offered to pay for the Greyhound Derby Final to be shown on Sky. And very quickly, I received a telephone call from Kevan Morretti. Kevan helps run RPGTV and was as helpful as possible in explaining Sky were insisting on a run of meetings, not just a one-off, and that he was coming up against brick-walls.I then went on to arrange a conference-call for the “Powers That Be” in Greyhound Racing, to explain this position, and try and get them back on track. It took weeks to arrange, and none present had anything like the drive or overall knowledge to make it happen. However, when Kevan came onto the call, it was clear that he was doing all he could, to push the deal back over the line.And push the deal over the line, is what he certainly did, Blog. Kevan Morretti has made a HUGE difference to Greyhound Racing and this should be recognised. THANK YOU, KEVAN!In other news:Ben’s Food Vlog 63: El Montero, Calle La Frontal, 37, 39210 Soto, Cantabria, Spain. Huge selection of Herbal Teas, for people to try, in this skiing area. Attractive and light. 18 Euro 3-course-lunch menu, represents excellent value. Warming and hearty stews. Hot Chocolate flavoured Herbal Tea (NAP). 7<span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>Over and out, B xlast_img read more

Researchers find potential therapeutic strategy to treat Alzheimers

first_img Source:https://www.ub.edu/web/ub/en/menu_eines/noticies/2019/02/038.html Reviewed by James Ives, M.Psych. (Editor)Feb 20 2019Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro) have identified a potential therapeutic strategy to treat Alzheimer’s, according to a study published in Journal of Neuroscience. The study shows, in a model of the illness in mice, that astrocytes -a type of cells in the brain- are able to release proteins that favour survival of neurons. According to the researchers, these results are a step forward in the understanding of the physiology of astrocytes, and they bring the chance to use this type of cells in therapeutic ways to treat Alzheimer’s.The study is led by Albert Giralt, Ramon y Cajal researcher at the UB, and also signed by the experts Jordi Alberch, Laura López Molina, Anna Sancho-Balsells, Ana López and Silvia Ginés, from the Faculty of Medicine and Health Sciences and UBNeuro, and members of the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED).Other participants in the study are José María Delgado García and Angès Gruart, from Universidad Pablo de Olavide, and other experts from Inserm (France) and Institut du Fer à Moulin (France).A promising strategy with important challengesAlzheimer’s disease is the most common dementia among people. Neurodegeneration in patients with this disease causes damage in memory and in other cognitive skills, sometimes combined with symptoms such as mood swings and personality changes. One of the most promising therapies against Alzheimer’s is the use of neurotrophic factors -a family of proteins favouring neuron survival- such as the brain-derived neurotrophic factor (BDNF). However, BDNF administration has important challenges, such as the lack of control of its release, which does not allow leading it specifically to the sick tissue nor releasing the proper amount of levels, mainly considering high doses can be neurotoxic.In this study, researchers studied BDNF generated by astrocytes, a type of star-shaped glial cells in the brain and the spinal cord. Astrocytes are affected by one of the neuroinflammation processes of Alzheimer’s, the astrogliosis, in which the glial fibrillary astrocytic protein (GFAP) and its coding gene are the most altered ones. In this context, researchers designed an experiment in which genetically modified mice suffer from Alzheimer’s and produce the BDNF protein depending on the GFAP levels. “With this design, from the moment neuroinflammation and pathology came up, the astrocytes could generate BDNF in the most affected areas of the sick brain. Therefore, the endogen reactions of the brain would regulate BDNF administration depending on the severity of the disease”, says Albert Giralt, member of the Consolidated Research Group on Physiopathology of Neurodegenerative Diseases of the UB.Effects of neuron formation and plasticityRelated StoriesNeural pathways explain the relationship between imagination and willingness to helpResearch sheds light on sun-induced DNA damage and repairMother calls for protein shake regulation after daughter diesThe study shows this method restores the production and release of the neurotrophin in the sick neuronal tissue when the pathology starts. Then, the BDNF generated by astrocytes regulates neuron formation in samples of in vitro neuronal cultures and has cognitive effects in transgenic mice models. “These results show for the first time that astrocytes, so far regarded as neuronal, can produce BDNF and have the necessary molecular mechanisms to release it in the areas of the diseased tissue which requires activity to favour neuronal survival”, says Albert Giralt.Researchers also note that “the singularity of the design of the experiment enabled the astroglial cells to ‘decide’ when, where and what amount to produce and give BDNF to altered brain tissues”. Therefore, “traits of the patient can mark endogenously and self-regulated the dose and other necessary therapeutic dynamics for a customized treatment”.Although the use of this therapy in humans is still far from taking place, researchers note the use of astrocytes out of induced pluripotent stem cells as a promising therapeutic strategy to be explored. “One possibility would be to derive induced stem cells from the skin of the patients, and then modify them genetically in vitro to express the BDNF under the GFAP promoter. Last, the last step would be to differentiate them and move them to the most altered brain regions of patients to boost survival and proper functioning of the existing neurons”, notes Albert Giralt.Viability in other neurodegenerative diseasesThis study using neuroinflammation processes makes it possible to apply them to other neurodegenerative diseases. “Our objective is, on the one hand, making this therapeutic approach plausible for the use in humans, and on the other, present similar approaches for neurodegenerative diseases in which neuroinflammation is a main symptom”, concludes the researcher.​ last_img read more

Student death Nigerian High Comm mulling redress wants to prevent a repeat

first_img Culture 07 Jul 2019 The ‘Mona Lisa’ Is Coming To Kuala Lumpur The High Commission said at the time of the arrest of Thomas Orhions Ewansiha, he was in possession of a student pass that was valid until Sept 23.It also confirmed that Ewansiha was a doctoral student of Management at Limkokwing University of Creative Technology.Ewansiha died on July 9 while in detention following a raid by the Immigration Department in Desa Aman Puri in Kuala Lumpur.Only July 11, a group of Nigerians took to protesting his death outside the Nigerian High Commission in Kuala Lumpur. Related News Related News World 10 Jul 2019 Bombed Tripoli migrant detention centre being emptied – U.N.center_img {{category}} {{time}} {{title}} World 10 Jul 2019 At least 100 migrants walk free from shelled detention centre in Tripoli PETALING JAYA: The Nigerian High Commission says it has taken the necessary steps to address the death of one of its citizens in a detention centre in Kuala Lumpur, with an eye towards seeking redress and preventing a repeat of such occurrence.It said it was working closely with Malaysian authorities and was awaiting the results of the autopsy report.”The High Commission has equally taken note of the concerns of Nigerians in Malaysia. The High Commission assures that necessary steps are being taken towards addressing this unfortunate incidence with a view for a redress and to prevent such occurrence in the future,” it said in a statement on Saturday (July 13).It urged Nigerians in Malaysia to continue to be law-abiding and to cooperate with the authorities and the High Commission while investigations were on-going.last_img read more

Supreme Court orders commencement of work for Phase 4 of Delhi Metro

first_img Press Trust of India New DelhiJuly 12, 2019UPDATED: July 12, 2019 15:44 IST The EPCA report said that there was a “stalemate” in discussions between the central government and Delhi government on certain financial aspects of the project. (File Photo)The Supreme Court Friday ordered implementation of the 103.94 km, Phase 4 of the Delhi metro and directed the authorities concerned to commence construction work on the project.A bench comprising Justices Arun Mishra and Deepak Gupta was told by the counsel appearing for the Delhi government that they have agreed to give a go ahead to the Phase 4 of the Delhi metro.The apex court was hearing a matter in which the Environment Pollution Control Authority (EPCA) had recently filed a report stating that the approval for the project was held up since 2014.The EPCA report said that there was a “stalemate” in discussions between the central government and Delhi government on certain financial aspects of the project.”There is a stalemate in the discussions between the Union Government and the Delhi government on different financial aspects of the project. The Delhi government has on April 10, 2019 communicated its direction that DMRC (Delhi Metro Rail Corporation) would not start work of Delhi Metro phase-IV till these issues are resolved,” it said.The stalemate came under the apex court’s scanner which said it would pass order in the matter as the “project cannot wait”.The court was also told by the apex court that the project was “critical” and the pending issue should be resolved soon.The Centre had told the court that project financing has been done in consonance with the Metro Rail Policy of August 2017 and metro projects of other cities like Bhopal, Indore, Kanpur, Patna and Agra have been sanctioned on the same financial pattern as of Delhi metro phase-IV.The EPCA report had said that the project is “critical as it will add another 104 km to the network” and “it is designed to join the current network and will densify it and make the system more viable and attractive to commuters”.ALSO READ | Delhi Metro snag: Thousands stranded, traffic chokes Delhi-Gurgaon highway as Yellow Line collapsesALSO WATCH | Arvind Kejriwal announces free travel for women in Delhi Metro, busesFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Supreme Court orders commencement of work for Phase 4 of Delhi MetroA bench comprising Justices Arun Mishra and Deepak Gupta was told by the counsel appearing for the Delhi government that they have agreed to give a go ahead to the Phase 4 of the Delhi metro. The apex court was hearing a matter in which the Environment Pollution Control Authority (EPCA) had recently filed a report stating that the approval for the project was held up since 2014.advertisement Nextlast_img read more