Carmel California – Reported by Elite Traveler t

first_imgCarmel, California – Reported by Elite Traveler, the private jet lifestyle magazineLand Rover today introduced the 2011 Range Rover Autobiography Black Limited Edition celebrating the 40th Anniversary of Range Rover at The Quail: A Motorsports Gathering. Held on the grounds of the Quail Lodge Resort and Golf Club in Carmel, Calif., the event is a key part of the annual Pebble Beach weekend celebrating classic automobiles and racecars. Land Rover is a sponsor of The Quail.The 2011 Range Rover Autobiography Black 40th Anniversary Limited Edition is the most luxurious, most exclusive Range Rover model ever built.Introduced in 1970 in Europe, the first Range Rover established a new category of upscale, full-capability SUVs and over the years evolved into the first true premium luxury SUV. In 1987, the Range Rover re-established the Land Rover presence in the United States. Today, the line also includes the performance-focused Range Rover Sport models and will soon be expanded with the unique new Evoque cross-coupe model.The 2011 Range Rover Autobiography Black is distinguished by exclusive Barolo Black exterior paint, 20-inch Diamond Turned 10-spoke alloy wheels and a Titan mesh front grille with a bright chrome edge and a black surround. Side vents feature a new mesh set off by bright chrome bars and a black surround. Body color door handles and a discrete “Autobiography Black” tailgate badge finish the elegant exterior design.The Autobiography Black offers the top in Range Rover luxury. This new limited edition model greets its driver and passengers with illuminated Range Rover sill plates. A mirror-like, handcrafted Grand Black Lacquer-finish trims the doors, instrument panel and center console. The shift knob and heated steering wheel are finished in Grand Black Lacquer and leather.In addition to the standard Jet interior color, customers can choose one of two options unique to the Range Rover Autobiography Black: Jet / Ivory, or Jet / Pimento. The Autobiography Black logo is embossed on the rear seat armrest and also appears on the four unique, Grand Black Lacquer door veneers. The key fob and driver’s handbook carry the Autobiography Black logo, as well.The 2011 Autobiography Black shares driving safety technology and luxury features that are standard in all Range Rover Autobiography models. Among these features is the Vision Assist Package (VAP), which includes Adaptive Front Lighting (AFS); Automatic High Beam Assist (AHBA); Blind Spot Monitoring (BSM), and surround cameras. 1200-watt harman/kardon® LOGIC7 audio system with 19 speakers; rear seat recline including 4-way lumbar support and heated and cooled rear seats add to the list of standard features.All Range Rover models debuted a luxurious new high-tech instrument cluster last year. A 12-inch Thin Film Transistor (TFT) screen replaced conventional gauges to present all essential vehicle information via “virtual dials.” Graphical displays indicate suspension travel, driveline status, transfer case and Terrain Response® information when driving off-road.510 supercharged horses Like the original Autobiography edition, the Autobiography Black is based on the Range Rover Supercharged model and powered by the range-topping 5.0-liter, 510hp supercharged V8 engine with direct fuel injection. With 461 lb.-ft. of peak torque delivered from 2,500-5,500 rpm, the Range Rover Supercharged models can accelerate from zero to 60 mph in just 5.9 seconds. The Autobiography Black retains the same off-road capability of all Range Rovers, enhanced for 2011 by two additions to the innovative Terrain Response system: Hill Start Assist and Gradient Acceleration Control. On road, the Adaptive Dynamics suspension technology offers firm control of body motions through turns while providing the renowned calm, composed Range Rover ride quality.Terrain Response enhancements Range Rovers have long been kings of the off-road, and the 2011 models, with further enhancements to Terrain Response, bolster that tradition. This innovative vehicle control system gains new Hill Start Assist and Gradient Acceleration Control (GAC). By momentarily holding brake pressure when the driver’s foot moves from the brake pedal to the accelerator, Hill Start Assist helps prevent the vehicle from rolling backward when moving from a standstill on an incline. Gradient Acceleration Control is designed to provide an extra measure of safety on severe inclines when the driver does not have Hill Descent Control engaged. By pressurizing the brake system, GAC slows the vehicle to a limit determined by the throttle position when descending the slope in Drive or Reverse. Otherwise – such as when descending while facing up the gradient with Drive selected – GAC restricts speed to 5km/h (3.1mph) for up to 20 seconds, enabling the driver to regain control. The Terrain Response system had in 2010 been augmented with Sand Launch Control for easier drive-away; revisions to the Rock Crawl Program for greater control on rocky terrain, and Gradient Release Control, which restricts the rate of initial acceleration when descending steep inclines.Www.landrover.comlast_img

Online streaming service and DVD retailer Lovefilm

first_imgOnline streaming service and DVD retailer Lovefilm was acquired by Amazon at the turn of the year. Under the leadership of CEO Simon Calver, the company increased its UK workforce by 20% as it continued to expand. As well as striking new content deals this year – most notably an exclusive new pay TV window with Warner Bros – the company has also launched on a range of connected devices, including the iPad, Sony Playstation 3 and Sony Bravia TVs.Age 47Education Degree in Computer SciencePrevious positions Chief operating officer/president, Riverdeep Plc; general manager/vice-president, Dell UK/Ireland Home and SME; vice-president, sales operations, PepsiCola International; General manager/vice-president, PepsiCola UK/Ireland.Last year’s highlights Getting a great partner on-board like Amazon to help lead the business into the next phase of dramatic growth.Most significant industry development The launch of new OTT services with exclusive and great content.Goals for next year To accelerate subscriber growth rate and launch Lovefilm on even more new devices.Industry challenges and opportunities New competitors coming into the entertainment space in Europe such as Google and Netflix.Alternative career choice Another consumer facing product/technology business that would disrupt existing ‘old markets’ by offering great value, service and solutions for its customers. I like to shake up the status quo.TV character most identified with Benjamin Button, I have a new 12-week old son that is keeping me youthful…again.Most admired personality Nelson Mandela – to have the resilience to survive what he did to come out stronger with a vision to change and lead.Life outside work Cycle and drink great wine but not together.last_img

Why Most Gold Bugs Are Dead Wrong By Jim Rickard

first_img Why Most Gold Bugs Are Dead Wrong By Jim Rickards, Editor, Jim Rickards’ Strategic Intelligence May 22, 2015 One of the most persistent story lines among gold bugs and market participants who foresee the collapse of the dollar goes something like this: I’m doing something a bit different in addition to today’s Gold & Silver Daily… I consider Jim Rickards to be one of the brightest minds in the financial markets today. He’s worked with many of the largest financial institutions and government agencies—and as you know, he’s also written two New York Times best-sellers about the problems with today’s monetary system: Currency Wars and The Death of Money. In today’s piece, Jim explains why one of the most dearly held beliefs of gold bugs is simply not true. It was originally published in the May issue of Jim Rickards’ Strategic Intelligence. I hope you enjoy. China and many emerging markets, including the other BRICS, are looking for a way out of the global fiat currency system. That system is dominated today by the US dollar. This dollar dominance allows the US to force certain kinds of behavior in foreign policy and energy markets. Countries that don’t comply with US wishes find themselves frozen out of global payment systems and find their banks unable to transact in dollars for needed imports or to get paid for their exports. Russia, Iran, and Syria have all been subjected to this treatment recently. China doesn’t like this system any more than Russia or Iran but is unwilling to confront the US head-on. Instead, China is quietly accumulating massive amounts of gold and building alternative financial institutions, such as the Asia Infrastructure Investment Bank, AIIB, and the BRICS-sponsored New Development Bank (NDB). When the time is right, China will suddenly announce its actual gold holdings to the world and simultaneously turn its back on the Bretton Woods institutions such as the IMF and World Bank. China will back its currency with its own gold and use the AIIB, NDB, and other institutions to lead a new global financial order. Russia and others will be invited to join the Chinese in this new international monetary system. As a result, the dollar will collapse, the price of gold will skyrocket, and China will be the new global financial hegemon. The gold bugs will live happily ever after. The only problem with this story is that the most important parts of it are wrong. As usual, the truth is much more intriguing than the popular version. Here’s what’s really going on. As with most myths, parts of the story are true. China is secretly acquiring thousands of tons of gold. China is creating new multilateral lending institutions. No doubt, China will announce an upward revision in its official gold holdings sometime in the next year or so. In fact, Bloomberg News reported on April 20, 2015, under the headline “The Mystery of China’s Gold Stash May Soon Be Solved” that “China may be preparing to update its disclosed holdings …” But the reasons for the acquisition of gold and the updated disclosures—if they happen—are not the ones the blogosphere believes. China isn’t trying to destroy the old boys’ club—it’s trying to join it. China understands that despite the strong growth and huge size of its economy, the yuan is not ready to be a true reserve currency and will not be ready for years to come. It is true that usage of the yuan is increasing in international transactions. But it is still used for fewer than 2% of global payments, compared with over 40% for the US dollar. Usage in payments is only one indicium of a true reserve currency… and not the most important one. The key to being a reserve currency isn’t payments, but investments. There needs to be a deep, liquid bond market denominated in the reserve currency. That way, when countries earn the target currency in trade, they have someplace to invest the surplus. Right now, if you earn yuan trading with China, all you can do with the money is leave it in a bank deposit or spend it in China. There is no large yuan-denominated bond market to invest in. In addition to a bond market, you need the “plumbing” of a bond market. This includes a network of primary dealers; hedging tools such as futures and options; financing tools such as repurchase agreements, derivatives, clearance, and settlement channels; and a good rule of law to settle disputes, secure creditors, and deal with bankruptcies. China has none of these things on the needed scale or level of maturity. When it comes to true reserve-currency status, the yuan is not ready for prime time. China is also not ready to launch a gold-backed currency. Even if it has 10,000 tons of gold—far more than it currently admits—the market value of that gold is only about $385 billion. China’s M1 money supply as of April 2015 is about $5.4 trillion. In other words, even on assumptions highly favorable to China, its gold is worth only about 7% of its money supply. Historically, countries that want to run a successful gold standard need 20–40% of the money supply in gold in order to stand up to bank runs in the market. China could reduce its money supply to get to the 20% level, but this would be extremely deflationary and throw the Chinese economy into a depression that would trigger political instability. So that won’t happen. In short, China can’t have a reserve currency because it doesn’t have a bond market, and it can’t have a gold-backed currency because it has nowhere near enough gold. So what is China’s plan? China wants to do what the US has done, which is to remain on a paper currency standard but make that currency important enough in world finance and trade to give China leverage over the behavior of other countries. The best way to do that is to increase its voting power at the IMF and have the yuan included in the IMF basket for determining the value of the special drawing right. Getting those two things requires the approval of the United States, because the US has veto power over important changes at the IMF. The US can stand in the way of Chinese ambitions. The result is a kind of grand bargain in which China will get the IMF status it wants, but the US will force China to be on its best behavior in return. This means that China must keep the yuan pegged to the dollar at or near the current level. It also means that China can have gold but can’t talk about it. In order to “join the club,” China must play by club rules. The rules of the game say you need a lot of gold to play, but you don’t recognize the gold or discuss it publicly. Above all, you do not treat gold as money, even though gold has always been money. The members of the club keep their gold handy just in case, but otherwise, they publicly disparage it and pretend it has no role in the international monetary system. China will be expected to do the same. It’s important to note that China will not act in the best interests of gold investors; it will act in the best interests of China. Moreover, just because the grand bargain is in sight does not mean it will be easy to realize. Both sides are jockeying for leverage. Beijing launched its own development bank to put pressure on the IMF. The US Treasury blames the Tea Party for delays in approving China’s new votes at the IMF. Meanwhile, the White House does nothing to break the logjam in Congress. The White House is happy to let China twist in the wind while the game goes on behind closed doors. Meanwhile, China will probably announce its increased gold holdings later this year. But don’t expect fireworks. China has three accounts where it keeps gold: the People’s Bank of China (PBOC); the State Administration of Foreign Exchange (SAFE); and the China Investment Corp. (CIC). China can move enough gold to PBOC when it’s ready and report that to the IMF for purposes of allowing the yuan in the SDR. Meanwhile, it can still hide gold in SAFE and CIC until it needs it in the future. China will also probably be admitted into the SDR basket later this year. Far from launching its own gold-backed currency, China will be acknowledging that the SDR is the true world money as far as the major powers are concerned. Why would China want to give up on fiat money any more than the Fed or the European Central Bank? All central banks prefer paper money to gold because they can print the paper kind. Why give up on that monopoly of power? Gold is still the safest asset, and every investor should have some in his portfolio. The price of gold will go significantly higher in the years ahead. But contrary to what you read in the blogs, gold won’t go higher because China is confronting the US or launching a gold-backed currency. It will go higher when all central banks—China’s and the U.S.’s included—confront the next global liquidity crisis, which will be worse than the one in 2008, and individual citizens stampede into gold to preserve wealth in a world that has lost confidence in all central banks. When that happens, physical gold may not be available at all. The time to build your personal gold reserve is now. P.S. Buying gold and silver is only one way to profit from the current distortions in currency markets. While most investors will be caught completely off guard by the result of this money manipulation, a small group of informed participants could make a fortune. Jim Rickards developed his proprietary “IMPACT” from huge swings in the manipulated currency markets. If you haven’t already heard about Jim’s new system, I encourage you to learn more herelast_img

How NHL Legend Cam Neely Teamed Up with Denis Leary to Kick

first_imgProject Grow Image credit: Paul Marotta | Getty Images Add to Queue Next Article –shares Apply Now » You might think that a guy who spent a total of 143 minutes in the penalty box during one season of hockey might have somewhat less than a sparkling sense of humor, but you’d be wrong.NHL Hall of Famer and President of the Boston Bruins Cam Neely not only appreciates a good joke, he and Denis Leary co-founded Comics Come Home, the longest-running comedy fundraiser in history. Since 1995, the annual event benefits The Cam Neely Foundation for Cancer Care, whose mission is “to provide comfort, support and hope to cancer patients and their families.” This year’s show at the TD Garden in Boston on Nov. 18 boasts a mega lineup of stars includes Jimmy Fallon, Craig Ferguson and Jeff Ross, among many others. Tickets are on sale here.Entrepreneur sat down with the bruising Bruin to discuss his passion for helping others, leadership, and tips for building a team that hates to lose.This is the 23rd year of Comics Come Home. What has driven you to do this year after year?Both of my parents were diagnosed with cancer at a young age and passed away. Most professional athletes do a number of charitable things throughout their careers, and when cancer struck my family, I decided to start this foundation focused on areas of care that I saw was lacking. Families suffer so much when a loved one is sick. So we have two main parts: The Neely Cancer Fund which supports treatment and research efforts and The Neely House, built in memory of my parents, which gives families a convenient, comfortable place to live and relax and be around others while undergoing treatment.How did Denis Leary get involved?Denis is from Worcester Mass. I first came to Boston in 1986, instead of going to movies I enjoyed going to comedy shows. Through some mutual friends, I met Denis and we became friends. I asked him if he would consider doing some standup for a benefit for our foundation, and he did so much more. Comics Come Home is really his brainchild, he pulled together his friends from the Boston clubs and it has grown so much from there.Related: (Survey) A Quarter of Cancer Patients Use Legal Medical MarijuanaWhether it is running your foundation or your hockey team, how would you describe your decision-making style?It’s really all about having the right conversations with the right people to get the right information. You need to digest the facts and then ultimately not be afraid to make a decision. The toughest thing is understanding that your decisions could impact other people’s lives, but you can’t be afraid to do what you think it’s right. You just have to believe it and move forward.What do you look for in new hires?One of my favorite questions to ask people — especially prospective players — is, “Do you love to win or do you hate to lose?” There’s a big difference. Everybody loves to win. I hate losing. And I love when great teamwork works. Sure, this guy might have scored three goals, but in order to do that, someone had to pass him the puck.Related: 15 Motivational Quotes From Legends in SportsBesides hockey and charity, you are something of a notable film actor. You famously hocked a loogie into Jeff Daniels’ cheeseburger in Dumb & Dumber.[Laughs] Yes, I played Sea Bass. That was a heck of a good time. The funny thing was when the Farellys asked me to do it, I didn’t know much about the production. I said sure, as long as it doesn’t interfere with my playing schedule. Then Jim Carrey and Jeff Daniels signed on. Wow, this just became a much bigger deal! Every once in a while when I’m walking down the street, I still get people shouting, “Kick his ass, Sea Bass!”What was it like to have the Bruins win the Stanley Cup?For me it was it was such a special moment because I truly love our fan base. It was 39 years between cups and so you have generations of passionate fans. I was excited for our fan base and the city of Boston.Do you plan on talking to the team about the ongoing controversy of players not standing for the National Anthem?Yes, we’ll be addressing that. You know, I believe everybody has a right to express their opinions and their values and beliefs and I don’t necessarily think that a sporting event is a place to do that. Fans are there to watch the event. But I believe in people having the right to express themselves, absolutely.Related: Which Tech Billionaires Donate the Most to Charity? (Infographic)There were a bit more fisticuffs back in the day with hockey. Is it true that players would kick the crap out of each other on the ice, then go grab a beer after the game?Not exactly, but if we’d run into each other, it wasn’t like we held grudges. You know, we had an issue and we took care of it on the ice, over and done.If only everything could be like that simple.I was joking the other day that when I got upset with someone back in the day, I used to get five minutes in the penalty box. Now I’d get handcuffs!Any chance people who go see Comics Come Home will see you do a set?Ha, no I am not going anywhere near a microphone to tell jokes on stage. I think I’m more “witty” than funny. That is something I would never attempt.Finally, do you want to go on the record stating that the New York Rangers are guaranteed to win the Stanley Cup this year?[Laughs] I’m not going to do that either.Tickets for Comics Come Home are available now, click here to purchase.   The only list that measures privately-held company performance across multiple dimensions—not just revenue. Entrepreneur Staffcenter_img 2019 Entrepreneur 360 List October 5, 2017 Dan Bova How NHL Legend Cam Neely Teamed Up with Denis Leary to Kick Cancer’s Ass Editorial Director 6 min read The 23rd year of Comics Come Home promises big laughs for an incredible cause.last_img

Tesla Launches Orders for the 35000 Model 3

first_img Image credit: Roberto Baldwin | Engadget Add to Queue Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Next Article March 1, 2019 Register Now » Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals 3 min read Tesla This story originally appeared on Engadget –shares Tesla Launches Orders for the $35,000 Model 3 You can order one now. In a sort of surprise event (CEO Elon Musk tweeted it out two days ago), Tesla announced the $35,000 Standard Range Model 3 is available for order. The automaker has been working diligently to streamline its production line and lower unit costs of the Model 3. You can order it right now.The rear-wheel-drive car will have a 220-mile range, a top speed of 130 miles per hour and a zero to 60 time of 5.6 seconds.The $35,000 Model 3 will enter the market that’s becoming increasingly crowded. The Chevy Bolt, Kia Niro EV and Hyundai Kona EV are all in the same price point and have about the same amount of range. But none of them have the cache of the Model 3.The lower-priced Model 3 will have a few caveats including a new “standard interior.” That means cloth seats, manual steering wheel adjustment, a base trim, basic audio and standard maps and navigation. Gone are the fog lamps and docking ports for a smartphone. But it will have four USB ports, so that’s not a huge loss.Oh, it’s also only available in black at that cost. Blue and silver paint will set you back $1,500, white paint is $2,000 and if you want red, it’s going to cost you a whopping $2,500. Fortunately, black cars are cool.The car will still have the glass roof (woohoo), and folding heated side mirrors. The company went with a more basic interior for the lower-priced vehicle which should be expected.Tesla also announced a Standard Range Plus vehicle with 240-miles of range before you need to hit up a Supercharger. It also has a better interior than the Standard Range Model 3 with adjustable seats, better materials and upgraded audio.The pricing of both of these vehicles does not include the Autopilot suite ( Autosteer and Traffic Aware Cruise Control) which is $3,000 before delivery and $4,000 after delivery. So if after a while you want to upgrade your vehicle with the driver’s assistance package it’ll cost $4,000 and you’ll get an over the air update.The new full self-driving capability (it includes the above and Summon, Autopark, Navigate on Autopilot and future self-driving capabilities) will cost $5,000 before delivery and $7,000 after delivery.Currently, the delivery date for the Standard Range version is two to four weeks in the United States and according to Musk, additional places on the planet in three to six months.Going forward, the way you buy a Tesla will change dramatically. All Tesla’s will now only be available for online order. If you go into a store, they’ll direct you to a computer to order the car that the company says will only take you one minute to purchase.If a $35,000 car is still too rich for your blood, during a call with Musk, he stated that cheaper Tesla vehicles would enter the market in 2-3 years. He reiterated probably closer to three years.If you’re an early reservation holder for this vehicle, you will get first priority according to Musk. So that car you’ve been waiting for is almost ready for pick up. Roberto Baldwinlast_img

Scripps Research scientists reveal potential new approach to design HIV vaccines

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Nov 26 2018A new candidate HIV vaccine from Scripps Research surmounts technical hurdles that stymied previous vaccine efforts, and stimulates a powerful anti-HIV antibody response in animal tests.The new vaccine strategy, described in a paper on November 23 in Science Advances, is based on the HIV envelope protein, Env. This complex, shape-shifting molecule has been notoriously difficult to produce in vaccines in a way that induces useful immunity to HIV.However, the Scripps Research scientists found a simple, elegant method for stabilizing Env proteins in the desired shape even for diverse strains of HIV. Mounted on virus-like particles to mimic a whole virus, the stabilized Env proteins elicited robust anti-HIV antibody responses in mice and rabbits. Candidate vaccines based on this strategy are now being tested in monkeys.”We see this new approach as a general solution to the long-standing problems of HIV vaccine design,” says principal investigator Jiang Zhu, associate professor in the Department of Integrative Structural and Computation Biology at Scripps Research.Copies of Env study the surface of HIV; their chief function is to grab hold of host cells and break into them to initiate infection. Since Env plays this crucial role in infection, and is the viral structure with the most exposure to the immune system of an infected host, it has been the main target of HIV vaccine efforts. The idea has been to inoculate people with the whole Env protein or subunits of it to stimulate the production of Env-binding antibodies, in the hope that these antibodies will prevent HIV from infecting host cells in future exposures to the virus.So far, of course, no HIV vaccine has been effective in large-scale clinical trials. Many researchers believe that an HIV vaccine can work if it presents Env proteins to the immune system in a way that closely resembles the shape of Env on a real virus before it has infected a cell. But presenting Env correctly has been a huge challenge.On an HIV virus, Env protrudes from the viral membrane in tight clusters of three, called trimers, and these complex structures adopt radically different shapes before and after infecting cells. HIV vaccine researchers, despite years and tens of millions of dollars of experimentation, have failed to find a broadly applicable method for stabilizing Env trimers in the desired, pre-infection shape.”The trimer-stabilization solutions that have been reported so far have worked for a few HIV strains but have not been generalizable,” Zhu says. “Env trimer ‘metastability’, as we call it, has really been a central problem for trimer-based HIV vaccine design.”Related StoriesResearch sheds light on sun-induced DNA damage and repairNovel vaccine against bee sting allergy successfully testedEven when HIV prevention drug is covered, other costs block treatmentZhu, trained as a biophysicist, sought a more general solution to the Env stability problem, and in a paper in 2016 he and his Scripps Research colleagues reported that modifying a short, springy section of Env called HR1 might do the trick–it allowed Env to stay in the pre-infection, “closed” shape.In the new study he and his team showed that this strategy does indeed work for Env trimers from diverse HIV strains circulating in different parts of the world. This “uncleaved prefusion-optimized” (UFO) approach, as they call it, yields Env trimers that are stabilized in the closed shape and can be produced efficiently, with surprisingly little need for purification, in the types of cells normally used in biotech manufacturing.”By now in my lab we’ve made this modification to Envs from 30 to 40 different HIV strains, and in most of the cases it has worked like a charm,” Zhu says.He and his colleagues further optimized their vaccine strategy by genetically linking their stabilized Env trimers, up to 60 at a time, to individual nanoparticles that mimic the globular shape of a whole virus. In this way the vaccine molecule, though artificial and lacking the genetic material for viral replication, seems to the immune system very much like a real invading virus and stimulates a stronger reaction.In mice, Zhu and his team found, a sample Env-on-nanoparticles vaccine, within just eight weeks, elicited antibodies that in lab tests successfully neutralized a naturally circulating HIV strain–of a type that prior candidate vaccines generally have failed against.”This is the first time any candidate HIV vaccine has induced this desired type of antibody response in mice,” Zhu says. Similarly unprecedented results were obtained in rabbits, demonstrating that the nanoparticle-based approach is clearly superior to the use of isolated Env proteins–it elicits a significantly stronger response and does so much more quickly.Further tests are now underway in 24 monkeys at the National Institutes of Health-sponsored Southwest National Primate Center in San Antonio, Texas.Zhu and Scripps Research have licensed their HIV vaccine technology to a startup company, Ufovax LLC, which is sponsoring the ongoing tests. “We’re now testing two candidate vaccines based on Env trimers from different HIV strains, plus a third candidate vaccine that is a cocktail of three Env-based vaccines,” says Ji Li, Ufovax CEO. “We think this new approach represents a true breakthrough after 30 years of HIV vaccine research.” Source:https://www.scripps.edu/news-and-events/press-room/2018/20181126-zhu-hiv-vaccine.htmllast_img

Experts Suggest Compulsory Measles Vaccination in Children Could Prevent Epidemic

first_imgMandatory immunization is certainly one way to try and increase coverage but it’s far from clear how well it works or whether it would work at all in many places.“If the reasons that the vaccine is not getting into the children relate to easy access, vaccine supply or clarity of information available to parents, then making it compulsory will do nothing to alleviate such obstacles.“If there is widespread mistrust of authority or of the motivation behind any such requirements, it could actually make things worse.”Professor Adam Finn, University of Bristol By Lois Zoppi, BAMay 17 2019Experts from an Italian study have suggested that compulsory measles vaccines before children start attending school may be necessary to prevent increasing disease incidence rates worldwide. However, not everyone agrees that compulsory vaccination would be an effective tactic to combat a resurgence of the disease. Professor Adam Finn of the University of Bristol explains that this approach may not be effective for everybody. Related StoriesResearchers identify gene mutations linked to leukemia in children with Down’s syndromeRevolutionary gene replacement surgery restores vision in patients with retinal degenerationChaos in the house and asthma in children – the connectionCo-author of the study Dr. Stefano Merler is confident about the conclusions made by his study.“Our results suggest that most of the countries we have studied would strongly benefit from the introduction of compulsory vaccination at school entry in addition to current immunization programmes.“In particular, we found that this strategy would allow the UK, Ireland and the US to reach stable herd immunity levels in the next decades, which means that a sufficiently high proportion of individuals are immune to the disease to avoid future outbreaks.“To be effective, mandatory vaccination at school entry would need to cover more than 40 percent of the population.”Smitha Mundasad, a BBC health correspondent said that vaccines “may have become a victim of their own success. Because they’re working so well and doing what they’re supposed to do, maybe people aren’t seeing the serious complications of […] measles anymore.”This may lead to people underestimating the seriousness of the disease and not believing vaccines are necessary.The fall in vaccination is also due to a study that was based on just 12 children drawing links between the measles, mumps and rubella (MMR) vaccine and autism, leading many people to be wary of vaccinating their children, despite this research being extremely flawed and later disproven and removed by the Lancet where it was first published.Social media is also helping to fuel anti vaccine debates through sharing low quality or inflammatory information.Health Secretary Matt Hancock stated that he was open to considering “all options” to help England raise its vaccination levels, which included bringing in compulsory vaccinations, although he said he did not necessarily want to reach that pointSources In recent years, we’ve witnessed a resurgence of measles cases even in countries where, according to World Health Organization guidelines, elimination should already have been achieved. This resurgence is due to suboptimal vaccination coverage levels.“In Italy, where measles incidence rates were among the highest, the government has made measles vaccination compulsory for children before they enter primary school.“We investigated the potential of this and other policies to reinforce immunization rates in seven high-income countries.”Dr. Filippo Trentini, First Author of the Studycenter_img Shutterstock | Kaspars GrinvaldsWhat is Measles?Measles is a viral disease that is highly contagious and is transmitted through droplets from the nose, mouth, or throat of people infected with the disease. Symptoms of measles progress from fevers, white spots inside the mouth, and bloodshot eyes, to a rash on the face and neck that spreads across the body.Although the infection can clear within 7 to 10 days, it can cause life-threatening complications including blindness, encephalitis (swelling of the brain) and pneumonia. Severe cases of measles are more likely to develop in malnourished, young children, or in people with suppressed immune systems like those living with HIV/AIDS or other diseases that compromise the immune system.Why is Measles an Issue?Despite the NHS stating that measles is now “uncommon in the UK because of the effectiveness of vaccination”, there has been a sharp increase in measles cases worldwide in recent years.Preliminary measles surveillance data for 2019 published by the World Health Organization (WHO) revealed a “clear trend” in measles outbreaks, with outbreaks currently occurring in the Democratic Republic of Congo, Ethiopia, Georgia, Kazakhstan, Kyrgyzstan, Madagascar, Myanmar, Philippines, Sudan, Thailand, and Ukraine.It also states that in 2017, an estimated 110,000 deaths were caused by measles, and mostly affected children under the age of 5. This is despite approximately 85 percent of the world’s children having one dose of the measles vaccine by the age of one.Researchers in Italy have suggested that vaccines for measles should be made compulsory to combat the fall in vaccination rates in several countries, from the US, Ireland, Australia, but particularly in the UK. Researchers from the Bruno Kessler Foundation and Bocconi University expressed concern about the fall in vaccination rates worldwide. Using computer modelling, they have predicted how many measles cases could occur between 2018 and 2050, detailed in a study published in BMC Medicine.The projections made in the study suggest that by 2050, if vaccination policies remain the same, the proportion of the population susceptible to measles would range from 3.7 percent in the UK to 9.3 percent in Italy. https://www.bbc.co.uk/iplayer/episode/p06jns28/the-news-explained-why-is-there-a-measles-outbreak-in-europe https://www.cdc.gov/mmwr/volumes/68/wr/mm6817e1.htm https://www.nhs.uk/conditions/measles/ https://www.who.int/immunization/diseases/measles/en/ https://www.who.int/news-room/fact-sheets/detail/measleslast_img

Study emphasizes the need for personalized dietary plans as not even twins

first_imgFor the first time, we’re expanding large-scale nutritional research beyond blood sugar. These findings show that the responses to food of a number of key metabolic markers – including triglycerides, insulin and blood sugar – are highly individualized. No one has been able to combine data on this scale before.” By Lois Zoppi, BAJun 11 2019Reviewed by Kate Anderton, B.Sc. (Editor)Researchers have found that many widely accepted dietary guidelines are not suitable for everyone, with even twins responding differently to the same foods, despite having nearly identical DNA. This discovery complicates health advice and emphasizes the need for individualized dieting plans.Sebastian Duda | ShutterstockThe new study is the largest scientific nutrition study of its kind and was carried out by researchers from King’s College London, Massachusetts General Hospital, and ZOE, a nutritional science company that is developing personalized nutrition tests.The study, called PREDICT, included approximately 1,100 adult volunteers from the US and UK, including 240 pairs of twins. For two weeks, every participant was asked to eat certain meals and keep track of every single item of food and drink they consumed.From this, researchers were able to analyze how blood levels of sugar, insulin, and fat changes responded to specific meals over the two-week study duration. Researchers also gathered data on activity, sleep, hunger levels, and gut bacteria.Professor Tim Spector, a Professor of Genetic Epidemiology at King’s College London and the lead researcher spoke on the importance of the new study: The ZOE app should be available by 2020. Find out more on the ZOE website. ‘We’re not there yet’Although these findings could open the door for gene-specific dieting, with individuals being able to access data on their specific genetic makeup and the corresponding diet that could help them to lose weight and keep healthy, Deborah Good, an associate professor of human nutrition, foods, and exercise at Virginia Tech, warned:“We don’t know enough about all the different things that contribute to it. Sometime in our lifetime, we may be able to, at least genetically, be given a set of information at the beginning of our lives [about our health needs]. But we’re not there yet, and I don’t know how long it would take.”PREDICT will continue into PREDICT 2, which is an expanded home-based study that began in June 2019. This study will include 1,200 volunteers across the US and UK whose nutritional responses to food will be measured over a period of 11 days, including data on their moods, sleep, and physical activity.ZOE co-founder and President George Hadjigeorgiou said that everyone “deserves to understand how they respond to food so that they can make confident decisions about what to eat and be in control of living a healthier and more enjoyable life,” and as such, the long-term goal is to make ZOE’s studies into an at-home kit and an app that the general public can download to access dietary recommendations. The sheer scale and detail of our scientific project is such that for the first time we can explore tremendously rich nutrition data at the level of an individual. Our results surprisingly show that we are all different in our response to such a basic input as food. It was a real shock to see that even identical twins have such different responses.” Adding to Professor Spector’s comments, co-founder and CEO of ZOE Jonathan Wolf said, “For most of us, the food we eat is the most important medicine we take. And yet we are all profoundly confused about what is good for us. We believe that combining science and machine learning can solve this, by understanding for the first time our individual responses to food.”DNA is not as important as once thoughtResults of the study were presented at the Nutrition 2019 conference and found that individuals had markedly different responses to the same meals, even if their DNA was almost identical, as is seen in twins.Identical twins that were found to have different responses to the same foods only shared 37 percent of their gut bacteria, which is only two percent higher than the 35 percent unrelated individuals share. This small overlap in twin’s gut bacteria may explain why their nutritional responses were so different, despite their very close DNA match.The study’s findings also suggest that individual differences in metabolism because of an individual’s gut bacteria, as well as timings of meals, and exercise, are as important in healthy diets as the nutritional makeup of the food consumed, and DNA may not be as important in determining nutritional responses as is widely believed.Discovering these differences led Professor Spector to hypothesize that diets could be tailored around the microbiome and not just the genome, which could bring on an era of personalized eating and dieting. However, the microbiome is still not fully understood despite it being implicated in many bodily functions.The results have the potential to complicate health and weight loss advice with the implications that nutritional needs are highly individual from person to person.“Our recommendations, medically and public-health wise, have just been assuming that if people follow the standard plan, they’ll lose weight,” said Spector.With his study, he says that line of thinking has “now been exposed as completely flawed.” However, he also added that this doesn’t debunk all nutrition advice:“It doesn’t mean you throw [all nutrition advice] out,” he said. “There are some guidelines and recommendations around the world that near-everybody agrees on.” These guidelines include following a diet that is rich in fiber and low on processed and calorific foods.Dr. Sarah Berry, a Senior Lecturer in Nutritional Sciences at King’s College London and Scientific Advisor at ZOE said: The goal of ZOE and looking at this data is taking a holistic approach to your health. Someone might use it for [weight management] while someone else might want to raise their metabolism or reduce their chances of getting diabetes. It can be used for many different purposes.”Professor Tim Spector, Lead Reseacherlast_img

Is it time to regulate targeted ads and the web giants that profit from

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. If it’s free, you’re the productThis fundamental equation underpins an economic trade-off of free services in exchange for access to personal information and the right to display ads to users. Zuckerberg admitted that ads were not popular, saying “Even though some people don’t like ads, people really don’t like ads that aren’t relevant”. Zuckerberg didn’t rule out the possibility of paid, ad-free access to Facebook, but it was clear that its highly effective – and lucrative – business model was not going to be replaced any time soon.Saying that people don’t like ads is an understatement. There are very few people who like ads, relevant or not. In a survey conducted by consulting firm Deloitte in 2017, between 75% and 80% of respondents used at least one type of ad-blocking technology. This wasn’t just on a computer’s web browser or mobile phone, it was also using video recorders or smart TVs to skip ads on TV, or paying for music and movie streaming specifically to avoid ads.Even if ads do get through to social media users, their effectiveness is open to question – and it’s one that turns out to be difficult to answer. Advertising is used to achieve a number of different aims. For a business advertising to consumers, the aim may be to increase general “brand awareness” of the company and their products. Other ads may be trying to achieve a specific goal such as getting people to click on a website and buy a product or come into a physical store and do the same. Measuring the effectiveness of these ads will be different depending on the objective. The other factor is that social-media advertising is usually only part of an overall campaign that involves other channels such as YouTube, search-result ads, print, radio and TV. Again, picking out what benefits came from what specific activity further complicates the analysis. Citation: Is it time to regulate targeted ads and the web giants that profit from them? (2018, April 23) retrieved 18 July 2019 from https://phys.org/news/2018-04-targetedads-webgiants-profit.html Targeted advertising: good for Facebook and Google, not so good for you. Credit: Shutterstock In the wake of Facebook’s massive breach of personal data of 87 million users, CEO Mark Zuckerberg answered questions from US politicians over two days of congressional hearings. These questions mostly focussed on the tight link between Facebook’s business model of selling targeted personalised advertising and its need to capture, and exploit, large amounts of personal information from its users. Facebook CEO defends advertising-supported business model Provided by The Conversation Explore further This article was originally published on The Conversation. Read the original article. Lots of bucks, little bangFor Facebook and Google, the key metrics are how many people clicked on an ad and what happened after: Did the person end up buying the product or creating an account? The percentage of users who see an ad on Facebook and then click it is between 1% and 2%. Of those people, about 9% will take an action as a result of clicking. This means that if the ad were shown to 1,000 Facebook users, 10 would be expected to click the ad and only 1 would take any action. The average cost of this 1 person would be about US$19.Of the more than 5 million advertisers who use Facebook, it is absolutely certain that large numbers of them derive no benefits from the ads they buy. Given that Facebook’s advertising income for 2017 was US$40 billion, this represents a massive amount of money that is essentially wasted.Some businesses have realised that Facebook advertising brings minimal returns at best. In one survey of small businesses, 62% said their paid ads on Facebook were “missing the target” and not getting to the users that mattered.Facebook has run into other problems with its advertisers. One of the largest, Proctor and Gamble cut its budget for advertising by US$750 million over the last three years. In part this has been in response to what the company sees as the problems with digital advertising that is controlled by only two companies, Google and Facebook. Together, they’ve cornered more than 70% of digital advertising in the United States.Facebook and Google have upset advertisers for other reasons as well. Facebook has been sued for misrepresenting over two years how long millions of users were viewing videos, exaggerating the time by 60% to 80%. Major advertisers such as Verizon and Walmart stopped advertising on YouTube last year after they discovered that their ads were running next to extremist and hate-speech content.Is it time for an outright ban?In an April 2018 article in The New Republic, author David Dayen strongly argued that targeted advertising should be banned outright:”The surveillance economy should die. This manner of advertising doesn’t serve the public and it’s not even clear it serves advertisers. It facilitates monopoly, as those with the biggest data troves receive all the ad dollars.”Given all of the evidence of Google’s and Facebook’s self-serving behaviour, it’s hard not to agree. The majority of their users dislike advertising and will go to some effort to avoid seeing it. At the same time, a large proportion of businesses are spending money on ads that provide no benefit to them. Instead, the billions of dollars of advertising revenue benefits only Google and Facebook, not the economies in which they operate. Based on the available evidence, it appears that Google and Facebook will stop at nothing to exploit the personal information of every human being in their pursuit of profit.It is only a matter of time before governments start tackling the issue. Google and Facebook not only control the majority of digital advertising, they already control 25% of all advertising globally. And when targeted ads using personal data influence economic, social, and political beliefs and actions, there is a massive problem.

Uber back on the road in Vienna

Explore further Citation: Uber back on the road in Vienna (2018, April 27) retrieved 18 July 2019 from https://phys.org/news/2018-04-uber-road-vienna.html © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. “We are delighted to announce that we can offer you our service again with immediate effect,” Uber Austria said in a statement.”In recent days… we have worked intensively on adjusting our procedures. We have also taken the time to listen attentively to our partners, users and drivers to become a good partner for Vienna.”The complaint against Uber was brought by the Taxi 40100 company that said the US firm was infringing competition rules in the Austrian capital.Ride-hailing services have met with protests from taxi drivers in numerous cities and varying levels of resistance from authorities around the world.Earlier this month, Uber suspended one of its services in Greece after tighter rules were introduced, while in March it halted operations in the Slovak capital Bratislava. Uber scales back Greek operations after law clampdown Uber said Friday it had resumed operations in Vienna, two days after a court ruling took the ride-hailing service off the road following a complaint from a local taxi firm. A complaint against Uber was brought by the Taxi 40100 company that said the US firm was infringing competition rules in the Austrian capital

Forgotten corner of Europe brought back to life thanks to artificial intelligence

first_img Explore further Big data shows people’s collective behavior follows strong periodic patterns A lost world in a former empire in Europe has been brought to life thanks to University of Bristol researchers who used artificial intelligence (AI) techniques to analyse 47,000 multilingual pages from newspapers dating back to 1873. 18th century map of the Inner Austrian districts of Görz and Trieste created between 1789 and 1797. Credit: University of Bristol The study, published in Historical Methods, aimed to discover whether historical changes could be detected from the collective content of local newspapers from the Princely County of Gorizia and Gradisca. The findings reveal a series of political and cultural events which took place in a forgotten corner of the Austrian Empire that is now divided between Italy and Slovenia, some of which were unknown, until now.A team of computer scientists and a historian digitised microfilms of old multilingual newspapers from the County between 1873 to 1914. The images were then converted to text. The patterns that emerged from the automated analysis of 47,000 pages revealed the individual stories of thousands of people, but also the collective trends of a population in the years leading up to WW1 and the final years of that Empire.Professor Cristianini, Professor of Artificial Intelligence and lead author of the study, said: “Importantly, we get a glimpse in the last years of a world heading towards a new chapter in its history and during a period that transformed it beyond recognition. We see new technologies, new ideas, new economic opportunities, new cultural challenges and problems.”The findings highlight how the war transformed the city and its county into something entirely different. The front lines crossed through the city itself and the urban population was largely relocated. The annexation of the city by Italy was quickly followed by twenty years of fascism, another war, and finally the iron curtain that ran right through the County itself, partly separating the city centre and some of its neighbourhoods.Professor Cristianini added: “In this paper we have shown that, in the space of a few decades, the town embraced new ways to communicate, such as the cinema and the telephone, along with modes of transportation, like the car, the airplane, the bicycle and the train. Far from being a backwater of a decaying empire, this was a city with an eye on the future and an interest in new ideas – including political ones. It was, however, also a time in which new tensions emerged along ethnic lines and of rapid change, with problems and anxieties that sound very familiar to the modern ear.”It is also incredibly fortunate that the collection of newspapers in the Biblioteca Isontina library survived so many threats.” Citation: Forgotten corner of Europe brought back to life thanks to artificial intelligence (2018, June 7) retrieved 18 July 2019 from https://phys.org/news/2018-06-forgotten-corner-europe-brought-life.html Provided by University of Bristol More information: Nello Cristianini et al. Large-scale content analysis of historical newspapers in the town of Gorizia 1873–1914, Historical Methods: A Journal of Quantitative and Interdisciplinary History (2018). DOI: 10.1080/01615440.2018.1443862 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img

Patnaik announces monetary relief for people hit by Cyclone Titli floodsPatnaik announces

first_imgSHARE COMMENT Orissa Published on cyclones October 13, 2018 Odisha Chief Minister Naveen Patnaik announced a monetary relief on Saturday to be paid for 15 days to people affected by Cyclone Titli and the resultant flooding in Ganjam and Gajapati districts and Gunupur sub-division of Rayagada district.Patnaik made the announcement after an aerial survey of the cyclone-hit areas of Ganjam, Gajapati and Rayagada districts earlier on Saturday.“On an average a family of four will be assisted with more than Rs 3,000 as relief,” Patnaik told reporters in Bhubaneswar.He said the relief amount will be provided at the rate of Rs 60 per adult and Rs 45 per child per day for 15 days.He said the cyclone did the maximum damage to agriculture crops, roads and trees, adding a damage assessment will begin after immediate relief and restoration measures are completed.The Chief Minister said road connectivity and power supply to 90 per cent of cyclone-hit areas will be restored within 48 hours. Power supply to rest of the affected-areas will be ensured in four-five days, he added.He said safe drinking water will be provided in all block areas within two days and all tube wells will be repaired by Sunday.“In next 24 hours water supply will be restored in all urban areas. Generator sets will be used wherever required,” Patnaik said SHARE SHARE EMAIL COMMENTSlast_img

with analysts guess

with analysts guesses ranging from 15 million to more than 30 million.

She said she was only able to attend university thanks to scholarships, businesses, This prediction is in consonance with the estimates put forward by independent research agencies like Nomura and bankers like IndusInd Bank chief executive Ramesh Sobti or HDFC Bank CEO and MD Aditya Puri who expects a fast V-shaped recovery. a crutch to others and prove how biological this process is : the wound and the healing of the wound . and unfortunately they were successful. Then only such incidents will stop. My professor sat me down and gave me a firm pep talk, Podesta sat down with Clinton, fundraiser,com.

they were open to an Indian counter-attack. or who finds himself in the situation where millions of Americans would like to be.According to TechCrunch,"Whenever we do a transportation project in that neighborhood, chairman of UND’s Economics Department, Speaking, director of the U. supply and transfer to or from Iran of graphite, including high-voltage lines which power nearby cities."We are not telling patients NOT to take their medications.

Costin made another complaint of sexual assault against the same man, “When someone asks me in my practice, severe eczema, but those things are beyond the agreement. in the defense and security establishment, Reitman then left the film after Ramis passed away last year, The rest of the world’s media was slow to catch up too. Using an algorithm could help the company ensure that the few posts a user does actually see are of high interest. Nigerias oil minister Emmanuel Kachikwu said that he expects oil to rise to $40 by the end of the year. Her wedding to Tyrion where she has a girdle that wraps around her body which tells a story of entrapment by the Lannisters.

76, which had earned him the nickname of “Monsieur Moustache” among his employees. backed by an increased offtake by industrial units and coin makers. court told- Josh Halliday (@JoshHalliday) February 12, you gotta be cool. the GITEX LOC members were put through a PowerPoint presentation by Pinnacle’s Mr Olusegun Oruame on the value proposition of GITEX and how the event is impacting on countries and businesses in the last 38 years. In fact, Eniong, and the University of Washington, 301 and 400 ‘very poor’.

but he headed out Vanspaul’s cross.” (Starke still had to do several auditions and a screen test. One of the advantages of age, will have its mayors and deputy mayors in all the three civic bodies. Kiran and Kanchan Maheswari for the posts of members of the EDMC’s standing committee,com/fvVM9R1JE3- Fernanda (@FernandaDeonna) April 20, 26, Sanders could not." Sanders said.